Abstract
We investigated the syndromes of the Sini decoction pattern (SDP). To obtain a common profile for SDP, we distributed questionnaires to 300 clinical traditional Chinese medicine practitioners. According to the survey, we concluded 2 sets of symptoms for SDP: (1) pulse feels deep or faint and (2) reversal cold of the extremities. Then we collected 24 individuals, and extracted their total mRNA of peripheral blood mononuclear cells for cDNA microarray experiments. 12 samples were used as the training set to identify the biomarkers for distinguishing the SDP and non-SDP groups. The remaining 12 samples were used as the test set. The test results indicated that the gene expression profiles of the identified biomarkers could effectively distinguish the 2 groups.