Abstract
The MIRD Schema had been investigated in this study, as the specific absorbed fraction (SAF) and the S-values were calculated by Monte Carlo method and the results were found to be consistent with literature values. Then, OLINDA/EXM and MCNPX were used to undergo internal dose assessment of the patient of 188Re-BMEDA-liposome. Through converting experimental mouse model data into anthropomorphic data, the effective dose was estimated. Three methods of dual programs have been designed for the internal dose evaluation; they were OLINDA/EXM Method 1, OLINDA/EXM Method 2 and MCNPX method. OLINDA/EXM Method 1 was designed with time dependent pharmaceutical distribution input while OLINDA/EXM Method 2 and MCNPX methods were designed with pharmaceutical distribution at 1 hour after injection, and also the effective half-life was replaced by physical half-life. The result obtained by OLINDA/EXM Method 1 was about 0.164mSv per 1MBq administered. The results obtained by OLINDA/EXM Method 2 and MCNPX method indicated that each patient would receive an effective dose of 0.197mSv per 1MBq administered and 0.180mSv per 1MBq administered respectively. After comparing the results obtained in combinations of OLINDA/EXM Method 1 vs. OLINDA/EXM Method 2, OLINDA/EXM Method 1 vs. MCNPX and OLINDA/EXM Method 2 vs. MCNPX, the differences of values were 17.0%, 9.6%, 8.5% respectively.