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2-烯丙基雙環[2.2.2]辛烯化合物的環重排置換反應之研究; 由2-甲氧酚製備順式-八氫?醇
Thesis

2-烯丙基雙環[2.2.2]辛烯化合物的環重排置換反應之研究; 由2-甲氧酚製備順式-八氫?醇

曹國緯
Masters, National Tsing Hua University
2007

Abstract

置換反應環重排置換反應 metathesisring rearrangement metathesis
The cis-hydrindanol skeleton can be found in the structures of many natural products, such as Botrydial、Sesquiterpene and Presilphiperfolan-8b-ol. Thus, in this thesis we report a short entry to functionalized cis-Hydroindenols from Diels-Alder reactions with masked o-benzoquinone (MOB) and the Ring- Rearrangement Metathesis (RRM).The bicyclo[2.2.2]octenone derivatives prepared for the RRM reaction were obtained from the Diels-Alder reaction of MOBs with various dienophiles, and followed by the addition of allylmagnesium bromide-CeCl3 complex. We have then successfully constructed cis-hydrindanol skeleton by this strategy and explored the scope and limitation of the target synthetic method.

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