Abstract
The natural products antillaridine and isojurubidine were isolated from Solanum plants by Coll et al. In 2001, Shiseido company in Japan was granted a patent, in which isojurubidine was reported as a skin lightening agent with bleaching effect on pigmention. We successfully synthesized antillaridine in 20% over all yield by using diosgenin as a starting material and Mitsunobu reaction as the key step. Then antillaridine was hydrogenated with 10% Pd/C to give isojurubidine in 80% yield. Antillaridine is the precursor of isojurubidine; we expect antillaridine could also exhibit skin lightening effect.