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7,7-Dimethyl-1-morpholin-4-yl-bicyclo[2.2.1]heptan-2-ol催化炔對醛不對稱加成反應
Thesis

7,7-Dimethyl-1-morpholin-4-yl-bicyclo[2.2.1]heptan-2-ol催化炔對醛不對稱加成反應

陳哲嘉
Masters, 國立清華大學, 化學系
2005

Abstract

催化炔對醛不對稱加成
The asymmetric addition of alkynylizinc to benzaldehyde were catalized by the chiral β-amino alcohol 3 derived from ketopinic acid in few stepts. When the addition of alkynylizinc to benzaldehyde was conducted at -20oC in the presence of 10 mol% catalyst, the alkynyl alcohol was obtained in 83% yield and 45% e.e.

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