Abstract
Now a day, we have surgery, radiation therapy and chemical drug therapy for cancer treatment. For metastatic cancer, we only have chemical therapy to prolong the life of patients. Trials for new drug therapies often take lots of time. We introduce a game model, that simulate the reaction between drug and tumor cell. We can get the trend of the tumor cell and the best strategy of drug dosage by solving this optimal problem. We also simulate the resistance mechanism of the tumor cell by introducing drug sensitivity database and cancer genes interaction network. With available trial reports, we can verify our model and make a comparison of static and dynamic dual drug strategies. In this thesis, we focus our experiment on Gemcitabine Paclitaxel combination therapy.