Abstract
Cancer has been the most cause of death since 1980s in Taiwan. Traditionally, there has many treatments of cancer such as surgery, chemotherapy, radiotherapy. These therapy are directly attack to the tumor cells. Although the killing effect are very well, but they also affect the normal cells even hurt other organs in the body. And if the tumor cells were not clearly been moved from the normal tissue, it may transfer to other place and cause a newly lesions. So the scientists and doctors are looking for a more precise and effect method to kill the tumor cells. Recently, Boron Neutron Capture Therapy ( BNCT ) is a ideal option to cure the cancer. The boron neutron capture therapy (BNCT) was started since 1936 by Locher, who suggested that two essential issues associated with BNCT: delivery of boron-10 to cancer cell and high quality and sufficient thermal neutron for irradiation. In the 1950s, Sweet started the clinical investigation on glioblastoma multiforme at Massachusetts Institute of Technology (MIT), however, 18 patients passed away from 10 days to 11.5 months after irradiation. 1960s, Hatanaka continued and modified the Sweet’s research work at Tokyo University got promising results in glioblastoma. The first time BNCT treatment in the history did not work out very well because of over-dosage. But due to the improvements of dosage-control and drug delivery system, it is much safer nowadays and become a potential therapy on advanced cancer therapy.