Abstract
Mitochondria are highly dynamic organelles that constantly undergo fission/fusion processes in response to environment. The dynamics of mitochondria determines mitochondrial integrity and function. In mammalian cells, starvation leads to unopposed mitochondrial fusion and drives mitochondrial elongation. In yeast, glucose starvation also induces mitochondrial hyperfusion. However, the mechanism remains unclear. To clarify the relationship between glucose starvation and mitochondria morphology, I examined the mitochondrial dynamics by classifying morphology in WT, Δsnf1 and Δtor1 strains in nutrient-deprived medium. I found that SNF1 pathway involved in mitochondrial hyperfusion under glucose starvation condition. In addition, mitochondrial fusion and fission balance is also affected by senescence. Mitochondrial fragmentation was presented in yeast senescent cells and resveratrol can mitigate this phenomenon. My results demonstrated that that resveratrol reduces ratio cells with fragmented mitochondria is not through SNF1 or TOR1 pathway.