Abstract
Nanoparticles have been used in biomedical application extensively. For iron oxide nanoparticles, known as SPIO or USPIO, it has applied to be a negative contrast agent to investigate the reticuloendothelial system such as liver, spleen and lymph nodes in MRI. For gold nanoparticles, it had been used for the optical imaging or color sensing. The combined of gold and iron oxide nanoparticles, Au-Fe3O4 had been synthesized as dumbbell-like (DBNPs) and flower-like (FLNPs) composites. The heterostructures of Fe3O4 have not been analyzed the ability of contrast by the morphological effect. In this study, we had evaluated the morphological effect on T2 relaxation. In biomedical application, we had used DBNPs to reaction with tau protein, related with Alzheimer’s disease. Tau protein is the normal component in structure in the neuron cell. In unknown pathogenesis, tau protein release to cerebral spinal fluid (CSF) and the neuron cell would breakdown. The disease severity is highly correlated with concentration of tau protein in CSF. The tau protein sensing at the prophase of disease is very important for prevent medicine. Even though the tau protein sensing was limited by the sensor design in this study, the sensor could be revising at the future work.