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Prediction of Transcription Factor Binding Sites from Unaligned Gene Sequences
Thesis

Prediction of Transcription Factor Binding Sites from Unaligned Gene Sequences

Liao, Yi-Sian
Masters, 國立清華大學, 電機工程學系
2008

Abstract

轉錄因子 Transcription factor
To know the regulation of gene transcription, transcription factor binding sites (motifs) are helpful information. In fact, cDNA microarray hybridization (ChIP array) has became a popular tool for recognizing motif from gene sequences. However the ChIp array can only map the probable sequence within 1-2 kilobases resolution. Our goal is to find out the motif binding site without the information of motif length. To reach this goal we design a computational program, base on the discriminator and binomial model to find the most possible patterns. And we compare our performance to the program called constraint-less Cosmo [1]. From the simulation results, we can prove that our program is better than Cosmo.

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