Abstract
Two types of new hydrophobic organic gold nanoparticles were synthesized, which contained hydrazone moiety. Upon irradiation with 312-nm UV light, these integrated gold nanoparticle-hydrazone hybrids cleaved DNA at the concentrations as low as 1 □M and 10 nM for hybrids with mixed and homogenous organic ligands, respectively. The mixed hybrids were prepared from pre-formed organothiolated gold nanoparticles through ligand exchange; the homogeneous hybrids were prepared by reduction of HAuCl4 with NaBH4 in the presence of functional thiolated molecules in toluene.