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Synthesis of Novel Pt-Complexes as Anti-Cancer Prodrugs with DNA-Cleaving Ability
Thesis

Synthesis of Novel Pt-Complexes as Anti-Cancer Prodrugs with DNA-Cleaving Ability

Jr-Yuan Lu
Masters, 國立清華大學, 化學系
2007

Abstract

DNA切割能力 抗癌前驅藥物 白金化合物 DNA-cleaving ability anti-cancer prodrug platinum complex
A synthetic pathway of new organoplatinum complex as anti-cancer prodrugs with DNA-cleaving ability was developed. On the other hand, we investigated the single-strand scission of phiX 174 RFI DNA by irradiated platinum complexes with UV light. Furthermore, the platinum complex 10 with carboxylic acid was expected for more study in the future.

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