Abstract
In the medical treatment at present time, we have three kinds of drug delivery ways which are taking medicines, hypodermic injection and pasting herbs on the skin. The effectiveness of drugs may decayed by taking medicines because of the circulatory system in human body. Hypodermic injection will hurt skin and be very painful. And the efficiency of pasting herbs on the skin is too slow. So we bring up a new idea about novel drug delivery system to overcome these disadvantages.The novel drug delivery system is a three dimensional electroplated oblique micro-needles arrays that fabricated by Micro Electric- Mechanical Systems (MEMS) technology. The micro-needles arrays we designed and fabricated could improve traditional needles disadvantages that are mentioned above. And provide a drug delivery system which is more comfortable and efficiency.After several generations micro-needles arrays, we make sure the best parameters and materials in the process. Because of the thick negative photoresist (e.g. THB-430N) can reach very high aspect ratio, so it can serve as mold of our micro-needles arrays. And then we can use evaporation and electroplate to finish our flat micro-needles arrays. We can also make use of experiences in fabricating flat micro-needles arrays to design next generation oblique micro-needles arrays process.The micro-needles we design and fabricated are made of metal such as nickel (Ni). The metal is electroplated and stronger than silicon (Si). Furthermore, the arrays with oblique needles can be inserted across skin easily and painless. This advantage may improve the efficiency of drug delivery systems.