Abstract
The influence of phospholipids based formulations on the in vitro percutaneous penetration of niacinamide was examined using abdominal skin of Wistar mouse mounted on Franz-type diffusion chamber. Transepidermal permeation through excised mouse skin and skin deposition of niacinamide from different formulations were assessed and compared. Liposome in water solution did not enhance the skin permeability of niacinamide, but when ethanol (20% v/v) was present in the donor with SPC-vitE or SPC-sc, permeability of niacinamide was increased. Liposome size and entrapment efficiency were determined. The encapsulation efficiency of niacinamide was found to be very low, however, the amount of absorbed niacinamide was nearly independent of the encapsulation and the vesicle size. Based on the results obtained, liposome components in solution have additive effect with a possible synergism in some cases.