Abstract
Transcranial magnetic simulations (TMS) is an effective tool for studying pathophysiology of dystonia as well as various other movement or cognitive functions of the brain. In previous studies, synaptic plasticity induced by TMS might be the key of recovering the abnormality in motor cortex. To study how TMS induces complex plasticity, we built computational models for pre-synaptic short-term plasticity and post-synaptic calcium dependent plasticity. With integration of these different time scale plasticity, Our model have successfully reproduced neural plasticity induced by a number of repetitive TMS protocols and Theta Burst stimulation (TBS).We will be able to provide insights into neuronal mechanisms underlying the effectiveness of TMS. Our result indicates that pre-synaptic short-term plasticity affects post-synaptic long-term plasticity by changing calcium concentration.