Abstract
In this thesis, a high-sensitivity biosensor is demonstrated by exploiting surface plasma(SP) enhanced transverse magneto-optical Kerr effect(TMOKE). The size of the device is 32×22 mm2 with the prism, microfluidic system and ferromagnetic plasmonic grating integrated on a single chip with the ability to deliver and detect bio-agents systematically. The SP grating made on an optimized composite Au/Fe/Au layer exhibits a very dispersive Kerr Parameter variation near the surface plasmon resonance wavelength. After the fabricating process, we characterized the magneto optical effect of the composite ferromagnetic grating and the capabilities for detecting bio-molecules. The maximum of measured Kerr signal is about 0.04 with convert factor of 0.087 nm-1. Through this integrated system, we have demonstrated the detection of sucrose solution in low concentrations. The calculated resolution for bulk solution is about 10-6 RIU, corresponding to a minimal concentration of 0.007 %(wt). Moreover, a preliminary experimental result on studying avidin biotin interaction was also shown. The sensitivity of avidin detection in PBS solution is about 31 nM, which is limited by the fluctuation of flowing media during measurement. The whole system is potential to accomplish a compact, noncontact optical detection scheme.