Abstract
The biodegradable polymers used as drug delivery carriers have been widely researched in the past years. In recent years, one of the drug delivery carrier, hydrogel, has also been developed. Synthetic hydrogel without the organic solvent will be reduced the purify steps in the following formulation. Hydrogels can contain amount of water and resemble nature living tissue, so it can be used as drug delivery carrier for protein, hydrophilic and hydrophobic drugs. In additionally, they are biodegradability, biocompatibility, non-toxicity, and own the various responses to the environment. Hydrogels are extensively application of their unique behaviors. In this study, we used the various mPEG-PVLA copolymers prepared by ring-opening polymerization of the mPEG, L-lactide, and various isomers of the δ-Valerolactone for the advanced drug delivery systems. Their structures will be measured by the GPC, 1H-NMR, DSC. Thermosensitive properties of the copolymers were tested using the tube inversion method. As a result, the sol–gel–sol transition temperature range could be varied, which might be very useful for its application as injectable drug delivery systems. The various hydrogel showed low cytotoxicity toward mouse fibroblasts 3T3 cell. After hydrogel particles were prepared, Teicoplanin is encapsulated. During 30 days accumulative drug release, 15 wt% mPEG-PγVLA has the most amount of release ratio 32%, and the most stable release is 15wt% mPEG-PαVLA, 28%. In thiis study, these amphiphilic diblock copolymers released Teicoplanin in a gradual mechanism and exhibited good stability, according to in vitro degradation behavior and in vitro drug release behavior. Because the materials degradation very slowly, the initial stage Teicoplanin release only by diffusion. As results, these hydrogels are very potential in long term controlled release of drug. controlled release system.