Abstract
Guanacastepene’s activity against methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus faecalis makes it of interest as a potential lead compound in the development of new antibacterial agents. We prepare trienyl compounds by combining side chain of the diene with 3-methylcyclohept-2-enol. We form the cyclohexane ring by an intramolecular Diels-Alder reaction, which has been used to form related [5, 4, 0]undecane. Now, we have the part of the carbon skeleton of Guanacastepene A. Finally, we study the influence of methyl group of dienophile on intramolecular Diels-Alder reaction