Abstract
Glaucoma has become the most common illness in the opthalmology. The way of administration for treating glaucoma is eyedrop. The limitation of this treatment mode are known as drug wastage, limited cornea exposure time, poor predictability of response and poor patient compliance. The main goal of this research is to develop the thermosensitivity polymer eyedrop for glaucoma patients. In the research, PNIPAAm were modified by grafting with PHEMA to prepare the glaucoma drug delivery system. Poly-N-isopropylacrylamide (PNIPAAm) is a thermoresponsible polymer. Its aqueous solution is clear and low viscosity at room temperature (25℃), and dehydration was occurred around 32℃ to produce sol-gel transition. At the same time, the shape of PNIPAAm is transitioned from random coil to globule. In ionic solution, the globule coagulates and becomes a polymer film. By taking of the advantage, the aqueous solution of PNIPAAm-g-PHEMA is applied to control the release of eyedrop. Through animal experiments, we see the PNIPAAm-g-PHEMA is better than the efficiency of traditional eyedrop.