Abstract
本論文所研究的反應系統為二硫化碳與鄰苯烯二胺之觸媒催化反應合成2-硫醇基苯駢咪唑及其衍生物，反應進行於勻相、兩相介質下。產物為2-硫醇基苯駢咪唑化合物可作為抗氧化劑、抑制劑及吸附劑，其衍生物則為醫療之鎮定劑。利用觸媒催化反應能在溫和的反應條件下獲得極高的產率，有效的改進以往製造方法的缺點。 2-硫醇基苯駢咪唑化合物之合成系統中，本文深入探討勻相和兩相系統之反應機構並獲得具體之結果，藉由不同的操作條件對反應速率之影響，合理提出反應系統之動力學模式。於不同的催化反應系統下勻相、液-液、氣-液兩相以及2-硫醇基苯駢咪唑衍生物之合成動力學，均透過實驗予以探討，簡化後之動力學模式虛擬一級速率式將可用來配適實驗結果。In this dissertation, 2-mercaptobenzimidazole (MBI), which wassynthesized from the catalyzed reaction of o-phenylenediamineand carbon disulfi- de by tertiary amine or quaternary ammoniumsalt either in a homogeneous solution or in a two-phase medium,was studied. The MBI derivatives were syn- thesized by reactantcatalyzed by quaternary ammo- nium salt in an alkaline solutionof KOH/organic solvent two-phase medium. The products MBI andits derivatives, which are important intermediates of specialtychemicals, are used as inhibitor, anti- oxidant, antiseptic,and adsorbent in industries, and durg for medicine care. Thereactions were greatly enhanced by adding a small catalyticamo- unt of tertiary amine or quaternary ammonium salt and/orin the presence of potassium hydroxide. The yields of productsMBI and its derivatives are in- creased by employing thepresent methods in this study. Several rigid results wereobtained from the synthesis of 2-mercaptobenzimidazole(MBI) ina ho- mogeneous solution and in a liquid-liquid two-pha semedium, and the derivatives of MBI by phase transfer catalysiswas also investigated experi- mentally in detail. Rationalkinetic models were built up based on the effects of theoperating conditions on the reaction rates. A pseudo-firstorder rate law model, was simplified from the o- riginalkinetic model, was sufficient to describe the behavior ofreaction in a homogeneous solut- ion, in a liquid-liquid two-phase solution and in a gas-liquid reaction solution.