Abstract
Robert F. Furchgott, Louis J. Ignarro and Ferid Murad have owned the Nobel Prize in 1988 due to finding nitric oxide as a signal molecule in the cardiovascular system. From then on, most people got interested in this nitric oxide molecule (NO). We do hope to make a disposable solid polymer-based biosensor with all the device in one chip which could real-time detect the variety of nitric oxide concentrations released from the cell. And this research put emphasis on the integrated device consists of an OLED as light source, NO probe and a photodiode as the detector. The NO probe is coming from the Institute of Chemistry, Academia Sinica Prof. Hung. We have known the PL quench of sold film of NO probe is due to its reaction with NO. Moreover, the advantage of the solid film of NO probe is highly selectivity and reversibility. We use OLED as the exciting light source to substitute for the LASER system and use organics photodiode (OPD) as detector. The photo-current could be response to the PL variation due to the probe react with NO. The size of the integrated chip is less than 10 cm2 and omits the larger optical system.