Abstract
Abstract This research explores how miniaturization may revolutionize chemical synthesis highlighting in particular environmental benefits of this new lab on a chip technology, which includes solvent less, in situ crystalline generation and integrated step-controllable reaction. Furthermore, the low required volume of preparing chemicals at point of use avoids the need to store and transport hazardous materials. We demonstrate two novel crystal synthesis chips. First, the crystalline of {[Cu(bpe)(SO4)(H2O)3]•3.5(H2O)•0.5(CH3OH)}n was successfully prepared based on laminar flow in order to reduce the amount of sample and solvent by Y-font channel chip. Traditional crystalline synthesis methods are neither environmental friendly nor economic; our second approach solves these problems. The double rotatable layers consists of two different reaction chambers (upper and lower layers) on chip made by PMMA can be used for high throughput without leakage and can easily be disassembled and reassembled. Our method is suitable for ordinary labs having no expensive equipment to fabricate microfluidic chips. In this study [Cu2(AcO)4(bpa)]n、{[Cu(AcO)2(bpa)(H2O)]∙2H2O}n、{[Cu(bpa)2(SO4)]•3.5H2O∙CH3OH}n have been synthesized in double rotatable layers chip and identified by SCXRD. This lab on a chip approach provides an alternative and promising method with environmental benefits and economic advantage.