Abstract
Hydroxyapatite (Ca10(PO)6(OH)2, HAp) is known for its biocompatibility in calcified tissues, and has been prepared in many forms for orthopedic and dental applications. HA is always directly implanted into the body, so that HAp with anti-bacterial property will extend its application and benefit the storage.In this study, our aim is to prepare effective antibacterial HAp powders and HAp coating on Ti-6Al-4V. Sol-gel method was employed to synthesize Ag-doped or Zn-doped HAp films, and the antibacterial test of HAp versus S. mutans was performed. With an addition of 100 ppm Ag+ ions in the sol-gel precursor, calcined HAp films showed growth suppression of the pathogen. Apparent inhibition zone was found for HAp film with increased Ag+ ions addition of 10000 ppm. But for the addition of Zn2+ ions, the inhibition zone can be found only when adding 10000 ppm and more Zn2+ ions to HAp precursor. The cytotoxicity tests showed that the HAp films with Zn2+ ions addition are better for the attachment and spread of human gingival fibroblasts (HGF-1).In order to reduce production cost of dental implants for future applications, addition of both Ag and Zn in to HAp films is suggested.