Abstract
Abstract This thesis dealt with the application of camphor-derived 1,3-dioxolan-4-one 101 in the synthesis of Cinatrin Family. Asymmetric Michael addition of 101 with methyl crotonate followed by α-hydroxylation with saccharin-type Davis reagent, then spontaneous lactonization gave highly functionalized lactone 104. Lactone 104 underwent olefin metathesis with 1-undecene in presence of second generation Grubbs catalyst to give lactone 108. Lactone 108 is an important precursor for the synthesis of nature product (+)-Cinatrin C3.