Abstract
AbstractAlkylene amine oximes including DmPn(AO)2、Bn*(AO) and Bn(AO)2 were synthesized and identified by NMR, Mass, Elemental analysisnts . Subsequently, using trace-level 99mTcO4- from generator was used to label these compounds in the presence of suitable concentration of Sn2+. The 99mTc-amine oxime complexes obtained were radioanalttically characterized simultaneously by solvent extraction, TLC, electrophoresis and HPLC. From the results, the labelling yield, lipophilicity, neutrality and stability of these complexes were realized .Nfsa cancer cells were utilized as our in vitro experiment's target and the 99mTc-complexes were injected into the cell culture in hypoxic condition . Uptake of the 99mTc-complexes by the cancer cells versus time was observed . In addition, an in vivo experiment was carried out using C3H/HeN tumor bearing mice . It is indicated from the study that one of the three 99mTc-complexes seems to have the potential to develop as a hypoxia imaging agent.