Abstract
The thesis dealt with the application of camphor-derived chiral ß-amino alcohol in catalytic asymmetric tandem Michael/Mannich reaction of diethylzinc to trans-chalcone. Utilizing the complex of (+)-MINBOL 6 (12.5 mol%) and Ni(acac)2 (0.5 mol%) catalyzed the enantioselective conjugate 1,4-addition of diethylzinc to trans-chalcone 12 afforded chiral zinc enolate 13. The chiral zinc enolate 13 was further reacted with imine 14a-k, which furnished Major products ß-amino ketone 4a-k (1S,2R,3S) with high enantioselectivity and good yield.