Abstract
This thesis dealt with the use of dihydroxyacetone as a C3 donor with 4-nitrobenzaldehyde in the asymmetric aldol reaction catalyzed by amines as organocatalyst. The effect of solvent, temperature, additive and mole ratio of reactants were studied. It was found that in the presence of 20 mol% catalyst 27 and 20 mol% benzoic acid additive in the DCM-propionitrile (7/1) mixed solvent system, afforded syn aldol product in 42% yield, moderate diastereoselevtivity (1:6.5) and good enantioselectivity (84%).