Abstract
This thesis dealt with the asymmetric oxidation of sulfide using in situ prepared chiral vanadium complex from tridentate ligands 100-112 with VO(acac)2. The tridentate ligands were synthesized from camphor derived amino alcohols with salicyaldehyde derivates. By using 1.0 eq hydrogen peroxide in portions with 1 mol% vanadium catalyst loading, the best result can be up to 88% ee. In most cases, although the enantioselectivity were moderate, yet the rate of sulfide oxidation was very fast compared with these reported in literature.