Abstract
This thesis dealt with the development of new chiral ligands, γ-amido thiol (10) and β-amino alcohol (11), based on γ-amino thiol(-)-MITH (2) and β- amino alcohol (+)-MINBOL (3), respectively. Furthermore, this thesis also dealt with the application of β-amino alcohol (11) in catalytic asymmetric addition reactions of diethylzinc and arylzinc to aldehydes to construct chiral secondary alcohols. Asymmetric ethylation using a stock solution of diethylzinc (1.1 M in toluene) was carried out in the presence of 0.5 mol % of β-amino alcohol (11) at room temperature and the (R)-secondary alcohols with high yields (up to 99 %) and ee values (up to 98 %) were obtained. On the other hand, asymmetric arylation was carried out in the presence of 2.5 mol % of β-amino alcohol (11) and the chiral diarylmethanols with high yields (up to 99 %) and ee values (up to 90 %) were obtained.