Abstract
The main idea of this thesis is to synthesize the pharmaceutical Anti-SARS moleculars by asymmetric reactions of 1,3-dioxolan-4-ones derived from camphorsulfonamide. Most of the pharmaceutical Anti-SARS molecular were considered as an AG7088 core structure with diversity of functionalities, so the same synthetic strategy was applied in our research. The central fragment 4 was synthesized in few steps from compound 85d with the lactone 55a which could be obtained easily by the procedures developed in our laboratory, then combined with molecular 62 and 64 to furnish the synthesis of analogs of AG7088. Up to now, combination of the molecular 62 with fragment 4 has been accomplished successfully in 6 steps with 31% yield.