Abstract
The characteristics of some drugs are not easy to be efficiently used in human body due to molecular weight, permeability, dissolution and etc. The nano-technology approach could improve the problem to enhance the capability in drug delivery for the target organ. We attempt to employ the nano-carriers to take the drugs into the blood circulation and remedy illness. We will develop the delivery capsule for transdermal drugs by MEMS fabrication to miniaturize the scale for painless remedy and evaluate the drug release through derma as well. The transdermal drugs are designed to patients for a long-term and consistent therapy. The new framework purposed in this paper composed of two layers. We employed PLA firstly as the needle material, which provides not only a tougher mechanical property to contribute a stronger fracture force, but also an outer shell to prevent the “initial burst” problem of the second layer. The second layer was made from appropriate blends of PLGA and drugs to furnish sufficient medical dose rate. We will to assessment the capability of insulin in transdermal delivery by PLA/PLGA polymer micro needles patch.