Abstract
Abstract Hepatocellular carcinoma (HCC), also called Liver cancer, is the sixth most common cancer worldwide and the leading cause of death amongst cirrhotic patients. Since there are asialoglycoprotein receptors, ASGP-R, in the surface of livers, ASGP-R can identify the structure of galactose. In this study, We tried to synthesize a lactose-bound compound, in order to drive the cancer-therapy compound into liver cells easily. Transformation of dinitrosyl iron complex (DNIC) [ Fe(CO)2(NO)2 ] into{Fe(NO)2}9-{Fe(NO)2}9 [Fe(μ-S-C2- Lactose)(NO)2 ]2 ( Sugar RRE ), triggered by Lactose-C2-Disulfide. The water solubility of Sugar RRE makes it difficult to get single-crystal X-ray structure, so the structure of Sugar RRE was validated by mass spectrum, infrared spectrum, UV-visible spectrometer and electron paramagnetic resonance (EPR).In series of assay, human liver cancer cell (HePG-2) was adopted as an experimental model . We expected that the binding of Sugar-RRE to ASGP-R is sospecific that RRE can penetrate into liver cancer cells easily, converted into DNICs and then release NO to kill liver cancer cells.