Abstract
This study aims to develop a comprehensive 2-in-1 PAD to detect the concentrations of Paraquat and creatinine in serum, which can help clinicians diagnose patients with severe Paraquat poisoning in a more rapid and geographically unrestricted manner. Due to its efficacy, Paraquat is the most widely used herbicide in the world. However, it is also highly toxic, and lethal in minute doses. The term SIPP (Severity Index of Paraquat Poisoning) is a common terminology in the diagnosis of Paraquat. The severity index of the poisoned patient is calculated using the Paraquat blood concentration (ppm) multiplied by the time taken between exposure to Paraquat and accepting therapy (hr). If the value exceeds 10, the patient is considered to be at high risk, and the survival rate will be significantly reduced. From a clinical point of view, "time" is a key factor in the treatment of Paraquat poisoning patients. In this study, the 2-in-1 PADs was developed to measure the concentration of Paraquat and creatinine. Creatinine concentrations serve as an indicator in the detection of renal function, can provide effective functional information, and would greatly assist the prompt diagnosis, treatment and rehabilitation of Paraquat poisoning patients.