Abstract
The bab and babab template coordinates are derived fromLatate dehydrogenase of the Protein Data Bank with the search IDcode 1HYH. Michael Rossmann had first found that the NAD-binding domain of the dehydro-genase all with the same bababbinding motif. It had now to be said as Rossmann motif ormononucleotide binding motif. The 1HYH protein is tetramerwith four symmmetry monomer. We choose any one monomer anddetermine the bab and babab motif by using rasmol with thefunction of cartoon ribbon.After checking the motif location,weget the 22-52 and 22-82 residue number of the protein as bab andbabab motif coordinate .Considering about the macro dipole,helix propensity,hydrophobicity and salt bridge, we had manycombination of the bab and babab structure motif.With the helpof molecular modeling program InsightII,we can design a moststable structurethat can still keep the bab and babab motif.