Abstract
Photothermal therapy has been highly noticed as a new treatment method in research fields recently. This method is by using photothermal sensitive material with near infrared (IR) light. Those materials have great absorbance of near IR, and can transform the light energy into thermal energy. Provide a new way to treat cancer cells or bacteria infection. Due to the high penetration of laser and its collimation, combining with photothermal sensitive material can produce heat for the efficient treatment. Our goal is to combine the MEMS (Micro Electro Mechanical Systems, MEMS) technology to produce polypyrrole microneedle patch, build a new photothermal therapy devices. In recent years, by using MEMS technology, researchers developed a new medical equipment technology - microneedle. Polypyrrole (PPy) was mostly often focused on its conductive characteristic, but furthermore which has excellent photothermal conversion capability, light stability, and with its excellent biocompatibility, making PPy a very promising photothermal therapy material. In our in vitro experiments, we adjusted the power of the near IR to manipulate the temperature. We used 0.5 W/cm2, 808 nm near IR with PPy microneedles to precede our experiment. In animal experiments, we demonstrate that this device has a good effect of bacterial inhibition. Prove the great potential of the PPy microneedle in photothermal therapy.