Abstract
As a noted topic of life science, brain research is aimed to find out the structure and function of human brain. To simplify the problem, a fruit fly, Drosophila, is chosen for research. In Drosophila brain, it is discovered that several brain controlling genes are very similar to human’s, and so as how they function.By using the advanced confocal microscopy technology, Drosophila brain can be scanned to get 2-D glomeruli images. These images were reconstructed into individual 3-D brain models. Biologists place neural networks and other structures into the brain model. In order to research and observation, the standard model is proposed. Rather than taking any one model as a standard, it’s better to average all individual models. The averaged brain model is a standard model for image database.Due to the importance of standard model, the registration algorithm for creating standard model is an interesting and useful topic. An automatic registration method for glomeruli is proposed for the issue. The initial position of source model and target model are different. We use the global registration to adjust the model globally. Local registration is then to adjust the position of individual glomerulus. Point-based warping is used for point’s movement. This method can be applied to automatic segmentation. First, we find the reliable edges on the original glomeruli images. Our algorithm can be applied to the image stacks. It is not necessary that the edge is closed. Our algorithm works on the closed contour and open contour.