Abstract
We previously reported the palladium-catalyzed cross-coupling reactions of orangodiboronates with acyl chlorides R1COCl, allenes R2R3CCCH2 to give an allylboronates R2R3CC(R1)B(OCCH3)2, which is one carbon-carbon bond formation. In this study, we wish to reporte the synthesis of two carbon-carbon bond formation via the palladium-catalyzed three-component coupling of allenes RR'CCCH2, arylboronic acids ArB(OH)2 and aromatic halides Ar'X. We also use 2-iodobenzyloxyallene as the starting material to get cyclization product ioschromene. Based on known palladium-allene and -allyl chemistry, we propose a mechanism to account for this palladium-catalyzed three-component coupling reactions.