Abstract
Acyl chlorides R1COCl, allenes R2R3CCCH2 and organotin reagents Bu3SnR4 undergo three-component coupling reaction in toluene in the presence of Pd(dba)2 to give functionally substituted a, b unsaturated ketones R2R3C=C(COR1)CH2R4. Based on known palladium-allene and -allyl chemistry, we propose a mechanism to account for this palladium-catalyzed three-component coupling reactions.