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鈷金屬錯合物催化碳-磷鍵偶合反應的研究
Thesis

鈷金屬錯合物催化碳-磷鍵偶合反應的研究

游曼彤
Masters, 國立清華大學, 化學系
2010

Abstract

鈷金屬錯合物催化 碳磷鍵 偶合反應 有機磷化合物 三芳香環膦化合物 膦氧化合物 二苯基膦 磷配位基 芳香鹵化合物 二苯基膦氧 二芳基膦-噁唑啉配位基 Cobalt-Catalyzed carbon-phosphorus (C – P) bond Coupling Reactions organophosphines unsymmetrical triarylphosphines triarylphosphine oxides diphenylphosphine Arylphosphine ligands aryl halides diphenylphosphine oxide phosphinooxazoline
Arylphosphine ligands play an extremely important role in homogeneous catalysis, and it’s also the crucial factor in determining the success of a reaction. In this thesis, we used an inexpensive cobalt-catalyzed to synthesize a species of unsymmetrical triarylphosphines and triarylphosphine oxides from diphenylphosphine or diphenylphosphine oxide with aryl halides. This is the first successful Co-catalyzed couplings of carbon-phosphorus (C – P) bond forming. In addition, we tried to study more details in the mechanism of the presenting coupling reaction. Interestingly, the reaction could also work without the reducing agent when the additive in the reaction condition was changed from Zn to ZnI2. Since the reaction failed to formation of carbon-phosphorus bond when replacing aryl halides by the organozinc reagent, the associative mechanism mediated by the organozinc reagent had been excluded. At the last part of this thesis, we attempted to synthesis of the phosphinooxazoline derivatves by this methodology. Finally, we got the corresponding complexes of two phosphinooxzaolines with cobalt iodides.

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