Abstract
Quinoline derivatives are abundant in nature. Quinoline scaffold plays an important role in drug development as their derivatives have shown excellent biological activities. As a result, many scientists try hard to develop a more efficient way to synthesize quinoline derivatives. In this thesis, we selected copper and iron catalysts because of their plentiful resources and cheaper prices. Two methods about quinoline synthesis are demonstrated here. Chapter 1 shows an approach toward the synthesis of quinolines via copper (II) promoted amines, formaldehyde, and internal alkynes for the intermolecular cycloaddition reaction. Chapter 2 gives a special method of synthesis quinolines via iron (III) catalyzed intermolecular cycloaddition and elimination reaction from imines and 1,4-epoxynaphthalene. Finally, this method was successfully applied to synthesize cinnolinium salts.