Abstract
AbstractTricalcium silicate (C3S) is one of the main constituent of industrial Portland cement which exhibits well self-setting ability. In this study we synthesized ZnxCa3-xSiO5 through solid-state reaction methods by adding ZnO, which is able to stabilize the structure of C3S and is anti-bacterial. And then, NaH2PO4 solution and collagen were added to prepare inorganic bone cement mixture. Mechanical and biological examinations were carried out and investigated.X-ray diffraction results showed that the addition of ZnO was able to reduce the phase separation of CaO, however, over addition led to ZnO impure phase. Zn0.25Ca2.75SiO5 was adapted for further studied. Bone cement mixed by NaH2PO4 solution had proper pH value (9~10), 30 minutes working time and 90 minutes setting time. Small amount collagen added mixture (1wt%) had lower early stage strength (10MPa) and longer setting time. The binding ability of collagen led the cement to having poor injection ability. As to the biological tests, added collagen would retard the releasing of ions. L929 fibroblast would attach onto the set materials directly, however hypodermic reactions were observed in the mice subcutaneous tests.Mixtures with large amount collagen (weight ratio of powder to collagen is from 5 to 1) were well deformable and had excellent mechanical strength after longer time setting. Their unique transitions of viscoelasticity property during the setting processes were worthy for further studies.Keyword: Portland cement, Tricalcium silicate (C3S), zinc oxide, collagen, compressive strength, injection ability, subcutaneous tests