Abstract
Hydroxyapatite(HA) has been wildly studied and used in bony implant, because HA has the advantages, such as free of cell toxicity, excellent bio-compatibility, and it is the major component of human bone. Beta-tricalcium phosphate(β-TCP) is also popular in implantation usage, due to its ability to release abundant calcium and phosphate ions that will provoke the bony growth. In this study, I aimed to prepare porous biphasic calcium phosphate materials as bony implant. We used a single phase HA and a foaming agent to form a porous biphasic(HA and β-TCP) material after one step calcination.The major foaming agent used is sucrose. HA and sucrose with the ratio 1 to 0.75 was found optimal. After being calcined at 1000℃ for 30min, a porous and biphasic material was obtained. The sucrose decomposed and evaporated during the process. The material has micro- and macro-pores, and the pore size ranges from 0~50 μm and 100~150 μm, respectively. The porosity was higher than 70%, HA could be higher than 60wt%, and the compressive strength was about 0.2~0.6 MPa. All these parameters could be adjustable by HA/sucrose ratio and calcination parameters. The synthesized material was free of cell toxicity, and there was no long-term inflammation in situ.