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A N-(2-aminophenyl)-5-(dimethylamino)-1-naphthalenesulfonic amide (Ds-DAB) based fluorescent chemosensor for peroxynitrite
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A N-(2-aminophenyl)-5-(dimethylamino)-1-naphthalenesulfonic amide (Ds-DAB) based fluorescent chemosensor for peroxynitrite

Ku-Kuei Lin, Shou-Cheng Wu, Kuang-Mei Hsu, Chen-Hsiung Hung, Wen-Feng LiawYun-Ming Wang
Organic Letters, 卷.15(16), 頁碼.4242-4245
08/2013
PMID: 23924291

摘要

Biochemistry Physical and Theoretical Chemistry Organic Chemistry
A dansyl derivative (Ds-DAB) was prepared and used as a fluorescent probe for peroxynitrite (ONOO - ) detection. The results showed that the addition of peroxynitrite to the aqueous solution of Ds-DAB would result in obvious fluorescence enhancement. This probe is highly specific for peroxynitrite in aqueous solution, avoiding interference from other reactive oxygen species (ROS) and nitrogen species (RNS). The advantages of high selectivity, fast reaction rate, and peroxynitrite bioimaging render Ds-DAB suitable for peroxynitrite detection. © 2013 American Chemical Society.

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