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A copper(ii) complex as an intermediate of copper(i)-catalyzed C-N cross coupling of N-phenylaniline with aryl halide by in situ ESI-MS study
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A copper(ii) complex as an intermediate of copper(i)-catalyzed C-N cross coupling of N-phenylaniline with aryl halide by in situ ESI-MS study

Chia-Kai Tseng, Mei-Chun Tseng, Chien-Chung Han and Shin-Guang Shyu
Chemical Communications, Vol.47(23), pp.6686-6688
21/06/2011

Abstract

Complexes [Cu(NPh 2 ) 2 ] - , [Cu(NPh 2 )I] - and K[Cu(phen)(NPh 2 ) (p-tolyl)] + were observed by in situ electrospray ionization mass spectrometry (ESI-MS) analysis of the copper(i)-catalyzed C-N coupling reaction under the catalytic reaction condition indicating that they are intermediates in the reaction. A catalytic cycle composed of a free radical path and a 2e oxidative addition path is proposed based on these observations. © 2011 The Royal Society of Chemistry.

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