A liposomal system capable of generating CO2 bubbles to induce transient cavitation, lysosomal rupturing, and cell necrosis

Min-Fan Chung; Ko-Jie Chen; Hsiang-Fa Liang; Zi-Xian Liao; Wei-Tso Chia; Younan Xia; Hsing-Wen Sung

doi:10.1002/anie.201205482

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A liposomal system capable of generating CO2 bubbles to induce transient cavitation, lysosomal rupturing, and cell necrosis

Journal article

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A liposomal system capable of generating CO2 bubbles to induce transient cavitation, lysosomal rupturing, and cell necrosis

Min-Fan Chung, Ko-Jie Chen, Hsiang-Fa Liang, Zi-Xian Liao, Wei-Tso Chia, Younan Xia and Hsing-Wen Sung

Angewandte Chemie - International Edition, Vol.51(40), pp.10089-10093

01/10/2012

DOI: https://doi.org/10.1002/anie.201205482

Abstract

cancer

cavitation

cell necrosis

liposomes

vesicles

Bubbling over: After endocytosis and intracellular trafficking to lysosomes, liposomes containing ammonium bicarbonate can be thermally triggered to generate CO ₂ bubbles (see scheme). These bubbles grow rapidly and collapse violently to induce transient cavitation, a process that can disrupt the lysosomal membrane and release lysosomal proteases, thus leading to cell necrosis. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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Title: A liposomal system capable of generating CO2 bubbles to induce transient cavitation, lysosomal rupturing, and cell necrosis
Creators - without role: Min-Fan Chung - Department of Chemical Engineering , National Tsing Hua University
Ko-Jie Chen - Department of Chemical Engineering , National Tsing Hua University
Hsiang-Fa Liang - Biomedical Technology and Device Research Labs , Industrial Technology Research Institute
Zi-Xian Liao - Department of Chemical Engineering , National Tsing Hua University
Wei-Tso Chia - National Taiwan University Hospital
Younan Xia - Georgia Institute of Technology
Hsing-Wen Sung - Department of Chemical Engineering , National Tsing Hua University
Publication Details: Angewandte Chemie - International Edition, Vol.51(40), pp.10089-10093
Identifiers: 9957772561206774
Academic Unit: Institute of Biomedical Engineering, College of Engineering, National Tsing Hua University
Language: English
Resource Type: Journal article

A liposomal system capable of generating CO2 bubbles to induce transient cavitation, lysosomal rupturing, and cell necrosis

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