PD-1, a negative coreceptor expressed on antigen-stimulated T cells and B cells, seems to serve as a 'rheostat' of the immune response. The molecular mechanisms of the functions of PD-1, in conjunction with the mild, chronic and strain-specific autoimmune phenotypes of PD-1-deficient mice, in contrast to the devastating fatal autoimmune disease of mice deficient in the immunomodulatory receptor CTLA-4, suggest that immunoregulation by PD-1 is rather antigen specific and is mainly cell intrinsic. Such unique properties make PD-1 a powerful target for immunological therapy, with highly effective clinical applications for cancer treatment. © 2013 Nature America, Inc.
- A rheostat for immune responses: The unique properties of PD-1 and their advantages for clinical application
- A rheostat for immune responses: The unique properties of PD-1 and their advantages for clinical application
- Taku Okazaki (Author) - Tokushima UniversityShunsuke Chikuma (Author) - Kyoto UniversityYoshiko Iwai (Author) - University of Occupational and Environmental Health JapanSidonia Fagarasan (Author) - RIKEN Center for Integrative Medical SciencesTasuku Honjo (Author) - Kyoto University
- Journal article
- 12/2013
- Nature Immunology, Vol.14(12), pp.1212-1218
- English