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Aerosol-induced lung injuries observed by synchrotron radiation X-ray phase-contrast imaging technique
期刊文章

Aerosol-induced lung injuries observed by synchrotron radiation X-ray phase-contrast imaging technique

Weisheng Yue, Guilin Zhang, Ping Liu, Jianqi Sun, Yeukuang Hwu, Jung Ho Je, Mingguang Tan 和 Yan Li
Nuclear Instruments and Methods in Physics Research, Section B: Beam Interactions with Materials and Atoms, 卷.262(2), 頁碼.304-312
2007
DOI: https://doi.org/10.1016/j.nimb.2007.05.032

摘要

Lung inflammation Phase-contrast X-ray imaging PM2.5 Shanghai Synchrotron radiation Nuclear and High Energy Physics Instrumentation
Adverse health effects are associated with the inhalation of a variety of atmospheric particles. To study the lung injuries caused by aerosol PM 2.5 , synchrotron radiation (SR) X-ray phase-contrast imaging technique was used. Nude mice were inoculated with PM 2.5 samples collected from suburban area (JD), industrial area (BS) and traffic tunnel (DPQ) of Shanghai. From X-ray phase-contrast images of lung tissues, apart from blood vessels and structures of alveoli, even hemorrhage spots of several microns caused by the inflammation were clearly observed. The studies showed that the PM 2.5 samples collected from the traffic tunnel (DPQ) produced higher level of lung injury, followed by the aerosol samples collected from industrial area (BS) and suburban area (JD). Our studies also helped us to understand the process of lung injuries caused by aerosol particles. © 2007 Elsevier B.V. All rights reserved.

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