An unusual approach to the synthesis of enantiomerically cis linear homoallylic alcohols based on the steric interaction mechanism of camphor scaffold

Chi-Lik Ken Lee; Cheng-Hsia Angeline Lee; Kui-Thong Tan; Teck-Peng Loh

doi:10.1021/ol049633z

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An unusual approach to the synthesis of enantiomerically cis linear homoallylic alcohols based on the steric interaction mechanism of camphor scaffold

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An unusual approach to the synthesis of enantiomerically cis linear homoallylic alcohols based on the steric interaction mechanism of camphor scaffold

Chi-Lik Ken Lee, Cheng-Hsia Angeline Lee, Kui-Thong Tan and Teck-Peng Loh

Organic Letters, Vol.6(8), pp.1281-1283

15/04/2004

DOI: https://doi.org/10.1021/ol049633z

Abstract

Camphor is used as the chiral auxiliary for the enantioselective synthesis of cis linear homoallylic alcohols. A range of catalysts, aldehydes, and solvents were investigated to obtain the optimum yield, enantioselectivity, and cis olefinic geometry.

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Title: An unusual approach to the synthesis of enantiomerically cis linear homoallylic alcohols based on the steric interaction mechanism of camphor scaffold
Creators - without role: Chi-Lik Ken Lee - Department of Chemistry , National University of Singapore
Cheng-Hsia Angeline Lee - Department of Chemistry , National University of Singapore
Kui-Thong Tan - Department of Chemistry , National University of Singapore
Teck-Peng Loh - Department of Chemistry , National University of Singapore
Identifiers: 9957773825306774
Academic Unit: Institute of Analytical and Environmental Sciences, College of Nuclear Science, National Tsing Hua University
Language: English
Resource Type: Journal article
Publication Details: Organic Letters, Vol.6(8), pp.1281-1283

An unusual approach to the synthesis of enantiomerically cis linear homoallylic alcohols based on the steric interaction mechanism of camphor scaffold

Abstract

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