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Analysis of an epidemiological model with age of infection, vaccination, quarantine and asymptomatic transmission
Journal article   Peer reviewed

Analysis of an epidemiological model with age of infection, vaccination, quarantine and asymptomatic transmission

Chin-Lung Li, Chun-Hsien Li and Chang-Yuan Cheng
Journal of the Franklin Institute
2022

Abstract

Control and Systems Engineering Signal Processing Computer Networks and Communications Applied Mathematics
In this study, we considered both control strategies -vaccination and quarantine- to solve an epidemiological problem. We used the SVIRS model as our baseline, to further classify infected individuals into classes according to them being symptomatic/asymptomatic and quarantined/non-quarantined. The age since infection is also relevant to describe the population dynamics by detailed features, among which, the age-specific quarantine rate poses some mathematical challenges since the possibility of an infected individual being quarantined exists at any age of infection. Firstly, we provided the model's well-posedness property, and formulated the basic reproduction number R 0 to determine whether the disease dies out or persists. Secondly, we demonstrated how backward bifurcation occurs in the proposed model under a complicated criterion, and explored it to observe the effects of certain parameters on the dynamics. We also investigated, as a special case, the global convergence to an endemic equilibrium using the Lyapunov functionals approach. We conducted some numerical simulations to illustrate the theoretical results and bi-stability due to the occurrence of backward bifurcation.

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