摘要
In order to reveal the biocompatibility of Fe 3 O 4 nanoparticles and bipolar surfactant tetramethylammonium 11-aminoundecanoate cytotoxicity tests were performed as a function of concentration from low (0.1νgml -1 ) to higher concentration (100νgml -1 ) using various human glia, human breast cancer and normal cell lines. Cytotoxicity tests for human glia (D54MG, G9T, SF126, U87, U251, U373), human breast cancer (MB157, SKBR3, T47D) and normal (H184B5F5/M10, WI-38, SVGp12) cell lines exhibited almost nontoxicity and reveal biocompatibility of Fe 3 O 4 nanoparticles in the concentration range of 0.1-10νgml -1 , while accountable cytotoxicity can be seen at 100νgml -1 . The results of our studies suggest that Fe 3 O 4 nanoparticles coated with bipolar surfactant tetramethylammonium 11-aminoundecanoate are biocompatible and promising for bio-applications such as drug delivery, magnetic resonance imaging and magnetic hyperthermia. © 2010 IOP Publishing Ltd.